A Tale of an Eternal Boredom

A story of the first and the biggest soap opera…

Сказка вечной скуки

Добрая хозяйка

Выхожу к жене:
- Представляешь, ты не налила в миску воды, захожу в туалет, а кошка почти целиком в унитаз залезла...
- Ну, ты дал попить, спустил воду?

— Фольклор

The Science of Addiction

Source:

Time, Time Inc., Issue July 16, p.42-47 (2007)

Keywords:

Biochemistry, Addiction, Neurotransmitters, Dopamine

Abstract:

For a species wired for survival we have an odd habit of getting hooked on things that can kill us. New research is revealing why -- and opening the door to the long-dreamed-of cure.

Full Text:

Some dates: 3000 BC Evidence of first wine industry along the banks of Nile 1492 Columbus travels to the West indies and sees Native Americans smoking tobacco 1600 Marijuana cultivation begins in U.S. with the Jamestown settlers, who used its strong fibers to make ropes and clothing 1919 National Prohibition Act 1935 A stockbroker and a surgeon (recovered and current alcoholoics) started Alcoholics Anonymous 1982 U.S. cocaine use peaks, with 10.4 million users 1985 Crack cocaine first appears in large cities like Miami and New York Few facts from the article: Dopamine biochemistry "We feel good when neurons in the reward pathway release a neurotransmitter called dopamine into the nucleus accumbens and other brain areas." Neurons in the rewards pathway communicate with dopamin in synapse: dopamine is released from axon and hits dopamine receptors on another neuron dendrite. At the same time, it's captured back by the axon, so that signal is not permanent. Another neuron may have synapse down the dendrite where it can release GABA (gamma-aminobutyric acid), another neurotransmitter which inhibits stimulation by the dopamine. Drugs mess up with this mechanism by forcing the release of more dopamine (e.g. meth), blocking capturing dopamine back (cocaine), or blocking the release of GABA (heroin, mortphine). Quotes "In the brain of addicts, there is reduced activity in the prefrontal cortex, where rational thought can override impulsive behavior" "What has to happen for that cue [for falling to the addiction again] to extinguish is not for the amygdala [unconscious part in reward pathway] to become weaker but for the frontal cortex [conscious mind] to become stronger." Interesting facts: Frontal cortex where cognitive functions happen can override addiction, but in addicts they seems to be significantly less active. Some drugs may inhibit its activity, but low cognitive functions make addiction and relapses significantly more likely. "To his surprise, Paulus found that 80% to 90% of the time, he could accurately predict who would relapse within a year simply by examining the scans." Addiction in U.S. Alcohol: 18.7 million people, 7.7% of population; 12,000 more try it every day; 2,000 Alcoholics Anonymous Drugs: 3.6 million are dependent; 8,000 try them every day for the first time; 700,000 in treatment; marijuana, cocaine and pain releivers are leading. Tobacco: 71.5 million people; 23.4% or men and 18.5% women smoke sigarettes; 44.3% of young adults 18 to 25 years smoke, highest rank in all age groups. Caffeine: 80% to 90% of Americans. 40% to 70% of them experience withdrawal if trying to quit. Food: 4 million people. Gambling: 2 million people. Shopping: 1 in 20 Americans.

The Bug


THE BUG

Important notice: All names in this text (except one first name) are taken arbitrary from the telephone 
directory. First names are taken from different pages than second names. Any similarity in names is accidental.

From: Alex Bach, field engineer
To: Vadim Zhukov, software engineer, Research & Development
Subject: bug in OS
Date: 4/1/97
Vadik, it looks like I found a next bug in OS. It’s something wrong with switching states. 
Best regards, Alex.

From: Vadim Zhukov, software engineer, R&D 
To: Dave Joyce, Manager, R&D
Subject: field engineers and a bug
Date: 4/1/97
Dave, I have a request from field engineers. It looks like they find another bug in ftstate. I 
see they start to like that. Vadim.

From: Dave Joyce, Manager, R&D
To: Vadim Zhukov, software engineer, R&D, OS group
Subject: request of field engineers
Date: 4/1/97
Vadim, what do you mean when you say "they like that"? Dave.

From: Vadim Zhukov, software engineer, R&D, OS group
To: Dave Joyce, Manager, R&D
Subject: request of field engineers
Date: 4/1/97
Just, that they like the bug. Vadim.

From: Dave Joyce, Manager, R&D
To: Tim Stock, Vice President
Subject: request of field engineers
Date: 4/2/97
Tim, field engineers said they like the bug in ftstate manager in version 5.
What we are supposed to do? Dave.

From: Tim Stock, Vice President
To: Tolia Perin, Manager
Subject: request of field engineers
Date: 4/3/97
Tolia, field engineers require some new feature they call “the bug” in ftstate in version 5. 
In what time you could validate the bug, if OS group will implement it?  Could we fit in 
time to include the bug in version 6 release? Tim.

From: Tolia Perin, Manager
To: Tim Stock, Vice President
Subject: request of field engineers
Date: 4/3/97
Tim, maybe it will require a bit more time. But I see no reason why it could be impossible. 
Tolia.

From: Tim Stock, Vice President
To: Tolia Perin, Manager
Subject: request of field engineers
Date: 4/4/97
OK, do that. Tim.

From: Tolia Perin, Manager
To: Dave Joyce, Manager
Subject: request of field engineers
Date: 4/5/97
Dave, field engineers require to implement the bug in ftstate manager for Series 6. This 
request is approved by Tim Stock. Tolia.

From: Dave Joyce, Manager
To: Tolia Perin, Manager
Subject: request of field engineers
Date: 4/5/97
Tolia, I don't understand what they like to have this time, but we will try, if possible. Do 
you know what "THE BUG" is supposed to be? Dave.

From: Tolia Perin, Manager
To: Dave Joyce, Manager
Subject: THE BUG
Date: 4/8/97
No, I just received a request. Could Will contact field engineering himself? It would be 
very useful for getting better specifications. I can issue Software Development Request 
for this task. Tolia.

From: Dave Joyce, Manager
To: Will Wagner, Supervisor
Subject: THE BUG
Date: 4/8/97
There is a request of field engineering to implement THE BUG in ftstate of Version 6. 
Could you estimate a time and time scheduling to do that? Dave.

From: Will Wagner, Supervisor
To: Keith Hensen, Vadim Zhukov, Ely McClain, Tom Hansen
Subject: New request
Date: 4/9/97
Hi, new joke from Dave :-(

> From: Dave Joyce, Manager
> To: Will Wagner, Supervisor
> Subject: THE BUG
> Date: 4/5/97
>
> There is a request of field engineering to implement THE BUG in ftstate
> of Version 6. Could you estimate a time and time scheduling to do that?
> Dave.

Who knows what does it mean? Will

From: Vadim Zhukov
To: Will Wagner, Supervisor
Subject: THE BUG
Date: 4/10/97
Well, a month ago I wrote some specifications for something like that. Maybe our big 
bosses at last understood importance of my proposals? Bad.

From: Will Wagner, Supervisor
To: Vadim Zhukov
Subject: THE BUG
Date: 4/11/97
OK, please, send them to me. I mean specs, not bosses. Will.

From: Vadim Zhukov
To: Will Wagner, Supervisor
Subject: THE BUG
Date: 4/12/97
See attachment. Bad.

From: Will Wagner, Supervisor
To: Dave Joyce, Manager
Subject: THE BUG
Date: 4/15/97
Dave, it may be complex to implement the request of field engineers in time. Do we really 
need to do so? Will

From: Dave Joyce, Manager
To: Tim Stock, Vice President
Subject: THE BUG
Date: 4/15/97
Tim, it's about the urgent request "THE BUG" of field engineering. Do we really need to 
implement it in version 6? Dave.

From: Tim Stock, Vice President
To: Dave Joyce, Manager, Tolia Perin, Manager
Subject: THE BUG
Date: 4/16/97
Dave, I suppose if the request is really urgent, there is no way. We have to do that.  Is it 
possible to defer something else, to fit in time?
Tolia, I understand you'll have a very short time for validation of THE BUG. Please, be 
ready for that.
Tim

From: Dave Joyce, Manager
To: Will Wagner, Supervisor
Subject: THE BUG
Date: 4/16/97
Will, there is no way. We have to implement THE BUG in version 6. Could we postpone 
anything else to fit in time? Dave.

From: Will Wagner, Supervisor
To: Dave Joyce, Manager
Subject: THE BUG
Date: 4/17/97
OK, I'll try to do something.

The time passed… The bug was implemented.

From: Alex Bach, field engineer
To: Vadim Zhukov, software engineer, R&D
Subject: bug in OS
Date: 7/1/97
Vadik, it's not April 1st now, and it looks like I really found a bug in OS. Alex.


Серебряный кабель

                          СЕРЕБРЯНЫЙ КАБЕЛЬ





Чарльз Меррил стоял у окна задумавшись и дымил своей пижонской 
трубкой, все больше сокращая остатки пригодного для дыхания воздуха в 
комнате.  Обычно это означало, что он наткнулся на нечто интересное и 
таинственное. Меррил был частным сыщиком и пользовался неплохой 
  

Жертвоприношение

                ЖЕРТВОПРИНОШЕНИЕ

     Старый  Жрец  выполз  из  своего убежища на площадь под 
Большой Водой. Площадь была пуста.  Ни  мусора,  ни  трупов, 
ничего  не  осталось. "Боги приняли жертву !" - провозгласил 
Старый Жрец, и из  своих  укрытий  и  убежищ  стал  вылезать 
народ.  С  радостными  криками они бросились к Большой Воде, 
  

1994 или 10 лет спустя

                                                Памяти незабвенного романа
                                                Дж. Оурелла "1984"
  

Приключения дяди Сэма в России

                 Приключения дяди Сэма в России

            Пьеса для детского сада с бизнес-уклоном

                        Действующие лица
Дядя Сэм  - американец  среднего класса,  приехавший в  Россию  в
           гости к племяннику.
Ваня      - его племянник и профессиональный переводчик.
Рэм       - молодой бизнесмен и приятель Вани.
  

Сказки племени Бум-Бум

                 С.-Петербург - Ленинград

                           1988

                  СКАЗКИ ПЛЕМЕНИ БУМ-БУМ

                   Сказка про арифметику

    Была на свете гора. Высокая, большая. А возле горы жило
два племени. Одно племя жило у пологого склона, и  когда  по
нему скатывались камешки, они звонко стучали  "бим-бим-бим",
  
***


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